Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth

Hypertension. 2021 Dec;78(6):1871-1884. doi: 10.1161/HYPERTENSIONAHA.120.17646. Epub 2021 Oct 25.

Abstract

[Figure: see text].

Keywords: biopterin; blood pressure; endothelial cells; pregnancy; vascular remodeling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biopterins / analogs & derivatives*
  • Biopterins / genetics
  • Biopterins / metabolism
  • Blood Pressure / physiology*
  • Endothelial Cells / metabolism*
  • Endothelium, Vascular / metabolism
  • Extracellular Vesicles / metabolism
  • Female
  • Fetal Development / physiology*
  • GTP Cyclohydrolase / genetics
  • GTP Cyclohydrolase / metabolism*
  • Humans
  • Mice
  • Mice, Knockout
  • Nitric Oxide Synthase Type III / metabolism
  • Placenta / metabolism*
  • Pregnancy
  • Uterus / metabolism*

Substances

  • Biopterins
  • Nitric Oxide Synthase Type III
  • GCH1 protein, human
  • GTP Cyclohydrolase
  • sapropterin