Knockout of Macula Densa Neuronal Nitric Oxide Synthase Increases Blood Pressure in db/db Mice

Hypertension. 2021 Dec;78(6):1760-1770. doi: 10.1161/HYPERTENSIONAHA.121.17643. Epub 2021 Oct 18.

Abstract

[Figure: see text].

Keywords: diabetes mellitus; glomerular filtration rate; hemodynamics; hypertension; kidney; nitric oxide; nitric oxide synthase.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / genetics*
  • Glomerular Filtration Rate / genetics*
  • Hemodynamics / genetics
  • Kidney Glomerulus / metabolism*
  • Mice
  • Mice, Knockout
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase Type I / genetics*

Substances

  • Nitric Oxide
  • Nitric Oxide Synthase Type I