2-Methoxyestradiol Ameliorates Angiotensin II-Induced Hypertension by Inhibiting Cytosolic Phospholipase A2α Activity in Female Mice

Hypertension. 2021 Nov;78(5):1368-1381. doi: 10.1161/HYPERTENSIONAHA.121.18181. Epub 2021 Oct 11.

Abstract

[Figure: see text].

Keywords: blood pressure; fibrosis; ovariectomy; phosphorylation; renin.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • 2-Methoxyestradiol / pharmacology*
  • 5,8,11,14-Eicosatetraynoic Acid / pharmacology
  • Angiotensin II / pharmacology*
  • Animals
  • Collagen / metabolism
  • Cytochrome P-450 CYP1A1 / physiology
  • Female
  • Group IV Phospholipases A2 / antagonists & inhibitors*
  • Group IV Phospholipases A2 / genetics
  • Hypertension / chemically induced
  • Hypertension / drug therapy*
  • Mice
  • Reactive Oxygen Species / metabolism
  • Receptors, Prostaglandin E, EP3 Subtype / antagonists & inhibitors
  • Receptors, Prostaglandin E, EP3 Subtype / physiology

Substances

  • Reactive Oxygen Species
  • Receptors, Prostaglandin E, EP3 Subtype
  • Angiotensin II
  • 5,8,11,14-Eicosatetraynoic Acid
  • 2-Methoxyestradiol
  • Collagen
  • Cyp1a1 protein, mouse
  • Cytochrome P-450 CYP1A1
  • Group IV Phospholipases A2