SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis

Circ Res. 2021 Nov 12;129(11):992-1005. doi: 10.1161/CIRCRESAHA.120.318479. Epub 2021 Oct 7.

Authors

Felicia Hartmann^#¹, Daniel J Gorski^#¹, Alexandra A C Newman^{2

3

4}, Susanne Homann¹, Anne Petz¹, Katherine M Owsiany^{2

3}, Vlad Serbulea², Yu-Qing Zhou⁵, Rebecca A Deaton², Michelle Bendeck⁵, Gary K Owens^#², Jens W Fischer^#¹

Affiliations

¹ Institute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany (F.H., D.J.G., S.H., A.P., J.W.F.).
² Robert M. Berne Cardiovascular Research Center (A.A.C.N., K.M.O., V.S., R.A.D., G.K.O), University of Virginia-School of Medicine, Charlottesville.
³ Department of Biochemistry and Molecular Genetics (A.A.C.N., K.M.O.), University of Virginia-School of Medicine, Charlottesville.
⁴ Cardiovascular Research Center in the Department of Medicine, New York University (A.A.C.N.).
⁵ Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada (Y.Q.-Z., M.B.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: atherosclerosis; extracellular matrix; galectin-3; mice; phenotype.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Actins / genetics
Actins / metabolism
Animals
Collagen / genetics
Collagen / metabolism
Galectin 3 / genetics
Galectin 3 / metabolism
Gene Deletion
Hyaluronan Receptors / genetics
Hyaluronan Receptors / metabolism
Hyaluronan Synthases / genetics
Hyaluronan Synthases / metabolism*
Hyaluronic Acid / metabolism*
Mice
Mice, Inbred C57BL
Muscle, Smooth, Vascular / cytology
Muscle, Smooth, Vascular / metabolism*
Myocytes, Smooth Muscle / metabolism
Phenotype
Plaque, Atherosclerotic / metabolism*

Substances

Acta2 protein, mouse
Actins
Galectin 3
Hyaluronan Receptors
Lgals3 protein, mouse
Hyaluronic Acid
Collagen
Has3 protein, mouse
Hyaluronan Synthases

Grants and funding