Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction

Circ Res. 2021 Nov 12;129(11):1021-1035. doi: 10.1161/CIRCRESAHA.121.319482. Epub 2021 Oct 6.

Qing-Jun Zhang^#¹, Yu He^#², Yongnan Li^#³, Huali Shen⁴, Ling Lin⁴, Min Zhu¹, Zhaoning Wang⁵, Xiang Luo¹, Joseph A Hill^{1

5}, Dian Cao¹, Richard L Luo¹, Raymond Zou¹, John McAnally⁵, Jun Liao⁶, Pietro Bajona^{7

8}, Qun S Zang⁹, Yonghao Yu¹⁰, Zhi-Ping Liu^{1

5}

¹ Internal Medicine-Cardiology Division (Q.-J.Z., M.Z., X.L., J.A.H., D.C., R.L.L., R.Z., Z.-P.L.), UT Southwestern Medical Center, Dallas, TX.
² Department of Clinical Laboratory, First Affiliated hospital of Guangxi Medical University, China (Y.H.).
³ The Sixth General Surgery, Biliary & Vascular surgery, Shengjing Hospital of China Medical University, China (Y.L.).
⁴ Institutes of Biochemical Science, Fudan University, China (H.S., L.L.).
⁵ Department of Molecular Biology (Z.W., J.A.H., J.M., Z.-P.L.), UT Southwestern Medical Center, Dallas, TX.
⁶ Department of Bioengineering, University of Texas at Arlington (J.L.).
⁷ Department of Cardiovascular and Thoracic Surgery (P.B.), UT Southwestern Medical Center, Dallas, TX.
⁸ Allegheny Health Network-Drexel University College of Medicine, Pittsburgh, PA (P.B.).
⁹ Department of Surgery, Stritch School of Medicine, Burn & Shock Trauma Research Institute, Loyola University, Maywood, IL (Q.S.Z.).
¹⁰ Department of Biochemistry (Y.Y.), UT Southwestern Medical Center, Dallas, TX.

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: biomarkers; collagen; extracellular matrix; fibrosis; myocardial infarction; myofibroblasts.