Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice

Hypertension. 2021 Nov;78(5):1335-1346. doi: 10.1161/HYPERTENSIONAHA.121.17435. Epub 2021 Oct 4.

Authors

Affiliations

¹ Department of Nephrology (A.H., Y.I., K.E., N.M., Q.D., H.I., Y.N., Y.K., M.A., T.K., M.M.), Kumamoto University Graduate School of Medical Sciences, Japan.
² Division of Internal Medicine, Kitasato University Medical Center, Kitamoto, Saitama, Japan (H.N.).
³ Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, and Barcelona Biomedical Research Park, Spain (J.A., C.L.-R.).
⁴ Department of Pharmacology and Molecular Therapeutics (S.K.-M.), Kumamoto University Graduate School of Medical Sciences, Japan.

PMID: 34601973
DOI: 10.1161/HYPERTENSIONAHA.121.17435

Abstract

[Figure: see text].

Keywords: aldosterone; blood pressure; hypernatremia; polyuria; transcription factor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amiloride / pharmacology
Animals
Blood Pressure / drug effects
Blood Pressure / genetics
Epithelial Cells / metabolism*
Epithelial Sodium Channel Blockers / pharmacology
Epithelial Sodium Channels / genetics
Epithelial Sodium Channels / metabolism
Gene Expression Profiling
Hypernatremia / genetics
Hypernatremia / prevention & control
Hypertension / etiology
Hypertension / genetics*
Hypertension / metabolism
Kidney Tubules / cytology
Kidney Tubules / metabolism
Mice
Mice, Knockout
RNA, Messenger / genetics
RNA, Messenger / metabolism
Sodium / urine
Sodium Chloride, Dietary / administration & dosage
Sodium Chloride, Dietary / adverse effects*
Transcription Factors / genetics*
Transcription Factors / metabolism

Substances

Epithelial Sodium Channel Blockers
Epithelial Sodium Channels
Nfat5 protein, mouse
RNA, Messenger
Scnn1a protein, mouse
Sodium Chloride, Dietary
Transcription Factors
Amiloride
Sodium