Inhibition of Soluble Epoxide Hydrolase Attenuates Bosutinib-Induced Blood Pressure Elevation

Hypertension. 2021 Nov;78(5):1527-1540. doi: 10.1161/HYPERTENSIONAHA.121.17548. Epub 2021 Oct 4.

Abstract

[Figure: see text].

Keywords: blood pressure; bosutinib; endothelium; incidence; mice, knockout.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aniline Compounds / pharmacology*
  • Animals
  • Arachidonic Acid / metabolism
  • Blood Pressure / drug effects*
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular / physiology
  • Epoxide Hydrolases / antagonists & inhibitors*
  • Epoxide Hydrolases / physiology
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nitriles / pharmacology*
  • Phenylurea Compounds / pharmacology
  • Piperidines / pharmacology
  • Proto-Oncogene Proteins c-abl / physiology
  • Quinolines / pharmacology*
  • Vasodilation / drug effects

Substances

  • 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea
  • Aniline Compounds
  • Nitriles
  • Phenylurea Compounds
  • Piperidines
  • Quinolines
  • Arachidonic Acid
  • bosutinib
  • Proto-Oncogene Proteins c-abl
  • Epoxide Hydrolases