Disruption of the Blood-Brain Barrier by Extracellular Vesicles From Preeclampsia Plasma and Hypoxic Placentae: Attenuation by Magnesium Sulfate

Hypertension. 2021 Nov;78(5):1423-1433. doi: 10.1161/HYPERTENSIONAHA.121.17744. Epub 2021 Oct 4.

José León^{1

2}, Jesenia Acurio^{1

3}, Lina Bergman^{4

5

6}, Juán López¹, Anna Karin Wikström⁴, Pablo Torres-Vergara^{3

7}, Felipe Troncoso^{1

3}, Fidel Ovidio Castro⁸, Manu Vatish⁹, Carlos Escudero^{1

3}

¹ Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile (J. Leon, J.A., J. Lopez, F.T., C.E.).
² Escuela de Enfermería, Facultad de Salud, Universidad Santo Tomás, Los Ángeles, Chile (J. Leon,.).
³ Group of Research and Innovation in Vascular Health (Group of Research and Innovation in Vascular Health), Chillan, Chile (J.A., F.T., C.E., P.T.-V.).
⁴ Department of Women's and Children's Health, Uppsala University, Sweden (L.B., A.K.W.).
⁵ Department of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden (L.B.).
⁶ Department of Obstetrics and Gynecology, Stellenbosch University, South Africa (L.B.).
⁷ Department of Pharmacy, Faculty of Pharmacy, University of Concepción, Chile (P.T.-V.).
⁸ Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepcion, Chillan, Chile (F.O.C.).
⁹ Nuffield Department of Women's & Reproductive Health. University of Oxford, Women's Centre, John Radcliffe Hospital, United Kingdom (M.V.).

Abstract

[Figure: see text].

Keywords: blood-brain barrier; exosomes; extracellular vesicles; placenta; pregnancy.