Comparison of Circadian Variation for In-Hospital Versus Out-of-Hospital Sudden Cardiac Arrest Survivors
Section snippets
Methods
Patients with SCA who were cared for at affiliated hospitals of the University of Pittsburgh Medical Center in Western Pennsylvania from 2002 to 2012 were included in this analysis. A total of 3,426 consecutive records of patients were identified using International Classification of Disease, 9th edition, codes for ventricular fibrillation (427.41), ventricular tachycardia (427.1), ventricular flutter (427.42), and cardiac arrest (427.5). Only patients aged 18 years and older, those without
Results
The baseline characteristics of the study cohort are listed in Table 1. Compared with OHCA survivors (n = 706), IHCA survivors (n = 518) were older, of higher body mass index, and had more co-morbid conditions with a higher CCI (p <0.001). Specifically, IHCA survivors had higher prevalence of atrial fibrillation, diabetes mellitus, hypertension, and chronic kidney disease and were more likely to be prescribed aspirin and β blockers. Compared with IHCA survivors, OHCA survivors had higher serum
Discussion
We demonstrated a clear circadian pattern of SCA in both hospitalized and community settings, suggesting an underlying common mechanistic pathway that transcends differences in physiology and activity levels between these 2 settings. Although the circadian pattern of SCA has been well documented in OHCA, it has rarely been examined previously in the IHCA population. One recent large study based on the American Heart Association's multicenter Get With The Guidelines-Resuscitation registry
CRediT Author Statement
Yicheng Tang: Data collection, analysis, and manuscript writing; Tarryn Tertulien: Data collection and analysis; Aditya Bhonsale: critical review of the manuscript; Krishna Kancharla: critical review of the manuscript; N.A. Mark Estes III: critical review of the manuscript; Sandeep K. Jain: critical review of the manuscript; Samir Saba: Concept of study, data analysis, and critical review of the manuscript.
Disclosures
Dr. Saba reports receiving research support from Boston Scientific and Abbott Inc.
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