Review article
Reverse cardio-oncology: Exploring the effects of cardiovascular disease on cancer pathogenesis

https://doi.org/10.1016/j.yjmcc.2021.09.008Get rights and content
Under a Creative Commons license
open access

Highlights

  • Cardiovascular disease (CVD) has cancer promoting effects.

  • Cardiac secreted factors and CVD-induced immune responses drive cancer pathogenesis.

  • Effects are CVD- and cancer-type specific.

Abstract

The field of cardio-oncology has emerged in response to the increased risk of cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a more complicated CVD-cancer relationship, wherein development of CVD, either prior to or following a cancer diagnosis, can also lead to increased risk of cancer and worse outcomes for patients. In this review, we describe the current evidence base, across epidemiological as well as preclinical studies, which supports the emerging concept of ‘reverse-cardio oncology’, or CVD-induced acceleration of cancer pathogenesis.

Keywords

Cardio-oncology
Cardiovascular disease
Cancer risk
Cancer progression

Cited by (0)