Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

Circ Res. 2021 Nov 12;129(11):975-991. doi: 10.1161/CIRCRESAHA.121.319643. Epub 2021 Sep 27.

Abstract

[Figure: see text].

Keywords: blood pressure; hypertension; inflammation; macrophages; plasma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Angiotensin II / metabolism
  • Animals
  • Axl Receptor Tyrosine Kinase
  • Cells, Cultured
  • Dendritic Cells / metabolism
  • Endothelial Cells / metabolism
  • Female
  • Humans
  • Hypertension / metabolism*
  • Intercellular Adhesion Molecule-1 / metabolism
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Interleukin-1beta / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Middle Aged
  • Monocytes / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Proto-Oncogene Proteins / metabolism*
  • Receptor Protein-Tyrosine Kinases / metabolism*

Substances

  • Intercellular Signaling Peptides and Proteins
  • Interleukin-1beta
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Proto-Oncogene Proteins
  • growth arrest-specific protein 6
  • Angiotensin II
  • Intercellular Adhesion Molecule-1
  • Receptor Protein-Tyrosine Kinases
  • Axl Receptor Tyrosine Kinase