NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis

Circ Res. 2021 Oct 15;129(9):e183-e200. doi: 10.1161/CIRCRESAHA.121.319153. Epub 2021 Sep 14.

Authors

Rebecca A Porritt^#¹, David Zemmour^#², Masanori Abe^#¹, Youngho Lee¹, Meena Narayanan¹, Thacyana T Carvalho¹, Angela C Gomez¹, Daisy Martinon¹, Chintda Santiskulvong^{1

3}, Michael C Fishbein⁴, Shuang Chen, Timothy R Crother¹, Kenichi Shimada¹, Moshe Arditi^#^{1

5}, Magali Noval Rivas^#¹

Affiliations

¹ Department of Pediatrics, Division of Infectious Diseases and Immunology, Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center (IIDRC) (R.A.P., M.A., Y.L., M.N., T.T.d.C., A.C.G., D.M., S.C., T.R.C., K.S., M.A., M.N.R.), Cedars-Sinai Medical Center, Los Angeles, CA.
² Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA (D.Z.).
³ CS Cancer (C.S.), Cedars-Sinai Medical Center, Los Angeles, CA.
⁴ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA (M.C.F.).
⁵ Smidt Heart Institute (M.A.), Cedars-Sinai Medical Center, Los Angeles, CA.

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: inflammasomes; inflammation; interleukin-1; monocytes; smooth muscle myocytes; vasculitis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Vessels / cytology
Blood Vessels / metabolism*
Cells, Cultured
Dendritic Cells / metabolism*
Fibroblasts / metabolism
Interleukin-1beta / metabolism
Macrophages / metabolism*
Male
Mice
Mice, Inbred C57BL
Mucocutaneous Lymph Node Syndrome / immunology
Mucocutaneous Lymph Node Syndrome / metabolism*
Muscle, Smooth, Vascular / cytology
Muscle, Smooth, Vascular / metabolism
Myocytes, Smooth Muscle / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein / genetics
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*
Receptors, Interleukin-1 Type I / metabolism
Stromal Cells / metabolism*

Substances

Interleukin-1beta
NLR Family, Pyrin Domain-Containing 3 Protein
Nlrp3 protein, mouse
Receptors, Interleukin-1 Type I

Grants and funding