Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4

Circ Res. 2021 Oct 29;129(10):909-926. doi: 10.1161/CIRCRESAHA.121.319687. Epub 2021 Sep 13.

Abstract

[Figure: see text].

Keywords: inflammation; ligands; lipoxygenase; macrophages; phenotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / genetics
  • Antigens, CD / metabolism
  • Antigens, Differentiation, Myelomonocytic / genetics
  • Antigens, Differentiation, Myelomonocytic / metabolism
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / metabolism
  • Chemokine CCL4 / genetics
  • Chemokine CCL4 / metabolism
  • Chemokine CXCL2 / metabolism
  • Female
  • Leukotriene B4 / metabolism*
  • Lipoxygenase / metabolism
  • Macrophages / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myocardial Infarction / metabolism*
  • Myocardium / metabolism
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Receptors, Leukotriene B4 / antagonists & inhibitors
  • Receptors, Leukotriene B4 / metabolism
  • Serine-Threonine Kinase 3 / genetics
  • Serine-Threonine Kinase 3 / metabolism*

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD163 antigen
  • Ccl2 protein, mouse
  • Ccl4 protein, mouse
  • Chemokine CCL2
  • Chemokine CCL4
  • Chemokine CXCL2
  • Cxcl2 protein, mouse
  • Ltb4r1 protein, mouse
  • Receptors, Cell Surface
  • Receptors, Leukotriene B4
  • Leukotriene B4
  • Lipoxygenase
  • Stk4 protein, mouse
  • Protein Serine-Threonine Kinases
  • Serine-Threonine Kinase 3
  • Stk3 protein, mouse