ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part I: Epidemiology, assessment of extrapulmonary conditions, candidate evaluation, selection criteria, and pathology statements

J Heart Lung Transplant. 2021 Nov;40(11):1251-1266. doi: 10.1016/j.healun.2021.07.014. Epub 2021 Jul 29.

Abstract

Patients with connective tissue disease (CTD) and advanced lung disease are often considered suboptimal candidates for lung transplantation (LTx) due to their underlying medical complexity and potential surgical risk. There is substantial variability across LTx centers regarding the evaluation and listing of these patients. The International Society for Heart and Lung Transplantation-supported consensus document on lung transplantation in patients with CTD standardization aims to clarify definitions of each disease state included under the term CTD, to describe the extrapulmonary manifestations of each disease requiring consideration before transplantation, and to outline the absolute contraindications to transplantation allowing risk stratification during the evaluation and selection of candidates for LTx.

Keywords: connective tissue diseases; consensus statement; extrapulmonary conditions; lung transplantation; transplant candidacy criteria; transplant evaluation.

Publication types

  • Practice Guideline

MeSH terms

  • Connective Tissue Diseases / diagnosis
  • Connective Tissue Diseases / epidemiology
  • Connective Tissue Diseases / surgery*
  • Consensus
  • Contraindications
  • Global Health
  • Humans
  • Lung Transplantation / standards*
  • Morbidity / trends
  • Patient Selection*