Morphologic investigation on Perceval S, a sutureless pericardial valve prosthesis: collagen integrity after collapsing-ballooning and structural valve deterioration at distance

Int J Cardiol. 2021 Oct 15:341:62-67. doi: 10.1016/j.ijcard.2021.07.050. Epub 2021 Jul 27.

Abstract

Perceval S is a self-expandable, stent-mounted bioprosthetic valve (BPV), with glutaraldehyde treated bovine pericardium, processed with homocysteic acid as an anti-calcification treatment. The stent is crimpable but the valve insertion is done surgically via a shorter procedure which does not require sutures. OBJECTIVES: MATERIAL AND METHODS: RESULTS: CONCLUSIONS: Collapsing and ballooning do not alter cusp collagen periodicity. Structural valve deterioration with stenosis, due to dystrophic calcification and fibrous tissue overgrowth, seldom occurred in the mid-term. Glutaraldehyde fixed pericardium has the potential to undergo structural valve deterioration with time, similar to well-known BPV failure. This supports the recommendation to pursue improvement of tissue valve treatment with enhanced durability.

Keywords: Bioprosthetic valves; Collagen crimping; Structural valve deterioration.

MeSH terms

  • Animals
  • Aortic Valve / diagnostic imaging
  • Aortic Valve / surgery
  • Bioprosthesis* / adverse effects
  • Calcinosis* / surgery
  • Cattle
  • Collagen
  • Heart Valve Prosthesis* / adverse effects
  • Humans
  • Pericardium / surgery
  • Prosthesis Design
  • Prosthesis Failure

Substances

  • Collagen