Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression

Circ Res. 2021 Aug 20;129(5):530-546. doi: 10.1161/CIRCRESAHA.121.319313. Epub 2021 Jul 22.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cardiovascular diseases; chemokines; emigration; myeloid cells; netrin-1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / cytology
  • Aorta / metabolism
  • Aorta / pathology
  • Cell Movement
  • Gene Silencing
  • Interleukin-10 / metabolism
  • Macrophages / metabolism
  • Macrophages / physiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Netrin-1 / genetics
  • Netrin-1 / metabolism*
  • Phagocytosis
  • Plaque, Atherosclerotic / genetics
  • Plaque, Atherosclerotic / metabolism*
  • Plaque, Atherosclerotic / pathology
  • Receptors, CCR7 / metabolism

Substances

  • Ccr7 protein, mouse
  • Ntn1 protein, mouse
  • Receptors, CCR7
  • Interleukin-10
  • Netrin-1