Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure

Hypertension. 2021 Sep;78(3):816-830. doi: 10.1161/HYPERTENSIONAHA.120.15423. Epub 2021 Jul 19.

Hainan Li¹, Huong Nguyen¹, Sai Pranathi Meda Venkata¹, Jia Yi Koh¹, Anjaneyulu Kowluru^{1

2}, Li Li³, Noreen F Rossi^{3

2}, Wei Chen^{4

5}, Jie-Mei Wang^{1

6}

¹ Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences (H.L., H.N., S.P.M.V., J.Y.K., A.K., J.-M.W.), Wayne State University, Detroit, MI.
² John D. Dingell VA Medical Center, Detroit, MI (A.K., N.F.R.).
³ Departments of Internal Medicine (L.L., N.F.R.), Wayne State University, Detroit, MI.
⁴ Department of Oncology (W.C.), Wayne State University, Detroit, MI.
⁵ School of Medicine, Karmanos Cancer Institute (W.C.), Wayne State University, Detroit, MI.
⁶ Centers for Molecular Medicine and Genetics (J.-M.W.), Wayne State University, Detroit, MI.

Abstract

[Figure: see text].

Keywords: GTP cyclohydrolase; blood pressure; cardiovascular diseases; homeostasis; nitric oxide.