Brief ReportPericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes
Graphical Abstract
Section snippets
Methods
We included consecutive adults without pre-existing LVADs who underwent new HeartMate 3 (HM3) LVAD implantation between October 1, 2015, and March 31, 2019, at Duke University Hospital. Patients with available clinical CT scans for preoperative anatomic or respiratory assessments within 6 months prior to LVAD implantation were included for PAT measurements.
Results
Among 140 patients who underwent HM3 LVAD implantation, 77 (5%) had available clinical CT scans for PAT-volume measurements preLVAD (median 7 days). The mean follow-up time was 1.6 ± 0.7 years. Preoperative and periprocedural characteristics are displayed in Table 1. The mean age was 61.6 ± 11.9 years, 78% were male, and the mean BMI was 29.1 ± 6.8 kg/m2. Compared to patients with below-median PAT volume, patients with above-median PAT volume (≥219 cm3) were more likely to have atrial
Discussion
In this population with end-stage HF undergoing LVAD, PAT and BMI were highly discordant. Higher PAT was not associated with either composite all-cause mortality, redo-LVAD surgery and cardiac transplantation or with composite incident LVAD-related hospitalizations. Obesity, a well-established risk factor in patients undergoing LVAD surgery, was, similarly, not associated with adverse outcomes following LVAD in our study population.
PAT is increasingly recognized as a distinct clinical entity in
Disclosures
VNR is supported by a National Institutes of Health (NIH) Training Grant (NIH 5T32HL069749-17); FR receives research funding support from Bracco Diagnostics. RTG receives consulting fees for Bayer Pharma, Invivo, DxTx Medical, Bard; Russell serves on the DSMB for Abbott Laboratories and receives consulting fees for Medtronic; MF is supported by NHLBI K23HL151744 from the National Heart, Lung, and Blood Institute, the American Heart Association grant no. 20IPA35310955, Mario Family Award, Duke
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