Original ResearchThe Added Value of Coronary Calcium Score in Predicting Cardiovascular Events in Familial Hypercholesterolemia
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Central Illustration
Key Words
cardiovascular disease
coronary artery calcium
coronary imaging
familial hypercholesterolemia
genetic disease
risk prediction
Abbreviations and Acronyms
ASCVD
atherosclerotic cardiovascular disease
AUC
area under the receiver-operating characteristic curve
AVR
aortic valve replacement
CAC
coronary artery calcium
HeFH
heterozygous familial hypercholesterolemia
LDL-C
low-density lipoprotein cholesterol
LLT
lipid-lowering treatment
MI
myocardial infarction
NRI
net reclassification improvement
PCSK9
proprotein convertase subtilisin kexin 9
Q
quartile
RE
risk equation
SAFEHEART-RE
Spanish Familial Hypercholesterolemia Cohort Study risk equation
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Drs Gallo and Perez de Isla contributed equally to this work.
© 2021 by the American College of Cardiology Foundation. Published by Elsevier.