Transcriptomic Profiling of Canine Atrial Fibrillation Models After One Week of Sustained Arrhythmia

Francis J A Leblanc; Faezeh Vahdati Hassani; Laura Liesinger; Xiaoyan Qi; Patrice Naud; Ruth Birner-Gruenberger; Guillaume Lettre; Stanley Nattel

doi:10.1161/CIRCEP.121.009887

Transcriptomic Profiling of Canine Atrial Fibrillation Models After One Week of Sustained Arrhythmia

Circ Arrhythm Electrophysiol. 2021 Aug;14(8):e009887. doi: 10.1161/CIRCEP.121.009887. Epub 2021 Jul 16.

Authors

Francis J A Leblanc^{1

2}, Faezeh Vahdati Hassani^{1

2}, Laura Liesinger^{3

4}, Xiaoyan Qi², Patrice Naud², Ruth Birner-Gruenberger^{3

4

5}, Guillaume Lettre^{1

2}, Stanley Nattel^{1

2

6

7

8}

Affiliations

¹ Faculty of Medicine, Université de Montréal (F.J.A.L., F.V.H., G.L., S.N.).
² Montreal Heart Institute, Montreal, Quebec, Canada (F.J.A.L., F.V.H., X.Q., P.N., G.L., S.N.).
³ Medical University of Graz, Diagnostic and Research Institute of Pathology (L.L., R.B.-G.).
⁴ BioTechMed-Graz, Omics Center Graz (L.L., R.B.-G.).
⁵ Technische Universität Wien, Institute of Chemical Technologies and Analytical Chemistry, Vienna, Austria (R.B.-G.).
⁶ Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Germany (S.N.).
⁷ Department of Pharmacology, McGill University, Montreal, Quebec, Canada (S.N.).
⁸ IHU LIFYC, Bordeaux, France (S.N.).

Abstract

[Figure: see text].

Keywords: atrial fibrillation; atrial remodeling; glutamate; microRNAs; transcriptomics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Atrial Fibrillation / genetics*
Atrial Fibrillation / physiopathology
Calcium-Binding Proteins / biosynthesis
Calcium-Binding Proteins / genetics
Disease Models, Animal
Dogs
Electrocardiography*
Female
Follow-Up Studies
Gene Expression Regulation
Heart Atria / physiopathology*
Male
Membrane Proteins / biosynthesis
Membrane Proteins / genetics
MicroRNAs / genetics*
RNA, Long Noncoding / biosynthesis
RNA, Long Noncoding / genetics
Time Factors
Transcriptome / genetics*

Substances

Calcium-Binding Proteins
DLK1 protein, human
MEG3 non-coding RNA, human
Membrane Proteins
MicroRNAs
RNA, Long Noncoding

Grants and funding

148401/CIHR/Canada