Malignancy-Associated Non-Bacterial Thrombotic Endocarditis Causing Aortic Regurgitation and Leading to Aortic Valve Replacement

Madiha Makhdumi; Dan M Meyer; William C Roberts

doi:10.1016/j.amjcard.2021.05.032

Malignancy-Associated Non-Bacterial Thrombotic Endocarditis Causing Aortic Regurgitation and Leading to Aortic Valve Replacement

Am J Cardiol. 2021 Sep 1:154:120-122. doi: 10.1016/j.amjcard.2021.05.032. Epub 2021 Jul 11.

Authors

Madiha Makhdumi¹, Dan M Meyer², William C Roberts³

Affiliations

¹ From the Baylor Heart and Vascular Institute, Dallas, Texas.
² The Departments of cardiac surgery, Dallas, Texas; Internal Medicine, Baylor University Medical Center, Dallas, Texas.
³ From the Baylor Heart and Vascular Institute, Dallas, Texas; Internal Medicine, Baylor University Medical Center, Dallas, Texas. Electronic address: William.Roberts1@bswhealth.org.

PMID: 34261592
DOI: 10.1016/j.amjcard.2021.05.032

Abstract

Described herein is a 48-year-old woman with metastatic ovarian cancer who developed aortic regurgitation considered clinically to be the result of infective endocarditis but operative resection of the three aortic valve cusps disclosed the valve lesions to be typical of non-bacterial thrombotic endocarditis (NBTE). Aortic regurgitation as a consequence of NBTE is rare but at least 9 cases have been reported previously.

Publication types

Case Reports

MeSH terms

Aortic Valve Insufficiency / diagnostic imaging*
Aortic Valve Insufficiency / etiology
Aortic Valve Insufficiency / surgery
Diagnosis, Differential
Endocarditis / diagnosis
Endocarditis, Non-Infective / complications
Endocarditis, Non-Infective / diagnostic imaging*
Endocarditis, Non-Infective / pathology
Endocarditis, Non-Infective / surgery
Female
Heart Valve Prosthesis Implantation
Humans
Middle Aged
Neoplasm Metastasis
Ovarian Neoplasms / complications*
Ovarian Neoplasms / pathology