A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling

Circ Res. 2021 Aug 20;129(5):568-582. doi: 10.1161/CIRCRESAHA.120.318364. Epub 2021 Jul 15.

Authors

William W Du^#¹, Jindong Xu^#^{1

2}, Weining Yang¹, Nan Wu¹, Feiya Li¹, Le Zhou¹, Sheng Wang², Xiangmin Li¹, Alina T He¹, Kevin Y Du¹, Kaixuan Zeng¹, Jian Ma¹, Juanjuan Lyu¹, Chao Zhang¹, Chi Zhou¹, Katarina Maksimovic¹, Burton B Yang^{1

3}

Affiliations

¹ Sunnybrook Research Institute, and Department of Laboratory Medicine and Pathobiology (W.W.D., J.X., W.Y., N.W., F.L., L.Z., X.L., A.T.H., K.Y.D., K.Z., J.M., J.L., C. Zhang, C. Zhou, K.M., B.B.Y.), University of Toronto, Canada.
² Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, China (J.X., S.W.).
³ Institute of Medical Science (B.B.Y.), University of Toronto, Canada.

^# Contributed equally.

PMID: 34261347
DOI: 10.1161/CIRCRESAHA.120.318364

Abstract

[Figure: see text].

Keywords: RNA, circular; collagen; fibroblasts; heart failure; peptides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carrier Proteins / genetics
Carrier Proteins / metabolism
Cell Adhesion Molecules, Neuronal / genetics
Cell Adhesion Molecules, Neuronal / metabolism
Cells, Cultured
Collagen / metabolism
Fibrosis
Humans
Mice
Myocytes, Cardiac / metabolism
Myofibroblasts / metabolism
Protein Binding
Protein Isoforms / genetics
Protein Isoforms / metabolism
Protein Serine-Threonine Kinases / metabolism
RNA, Circular / genetics
RNA, Circular / metabolism*
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / metabolism
Ventricular Dysfunction / genetics
Ventricular Dysfunction / metabolism*
Ventricular Remodeling*

Substances

Carrier Proteins
Cell Adhesion Molecules, Neuronal
ING4 protein, mouse
Protein Isoforms
RNA, Circular
Tumor Suppressor Proteins
Collagen
Protein Serine-Threonine Kinases
Sgk3 protein, mouse

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