Outcomes Following Aortic Stenosis Treatment (Transcatheter vs Surgical Replacement) in Women vs Men (From a Nationwide Analysis)
Section snippets
Methods
This longitudinal cohort study was based on the national hospitalization database covering hospital care from the entire French population, which have been previously described.8 The data for all patients admitted with aortic stenosis in France from January 2010 to June 2019 were collected from the national administrative PMSI database, which was inspired by the US Medicare system. Through this program, which was implemented in 2004, medical activity is recorded in a database, computed, and
Results
Between January 1, 2010, and June 30, 2019, 71,794 patients were identified in the database, including 22,380 female patients treated with TAVR, 21,414 men treated with TAVR, and 28,000 female patients treated with SAVR.
In the unmatched population of women and men who underwent a TAVR women were older, had lower estimated EuroSCORE II and cardiovascular risk factors and had less often a history of coronary artery disease or revascularization (Table 1). In the unmatched population of female
Discussion
In this propensity score-matched analysis, we observed that: Gender had no impact on long-term cardiovascular outcomes after TAVR. We observed lower rates of all-cause death during follow-up in women, this difference being driven by lower incidences of non-cardiovascular death, while cardiovascular mortality was not different. TAVR was associated with better short-term outcomes versus SAVR in women, while after 2 years follow-up, curves tended to cross, and rates of cardiovascular mortality,
Declaration of Competing interests
The authors declare the following financial interests/personal relations which may be considered as potential competing interests: CSE reports honoraria from Abbott and Biotronik. LF reports consultant or speaker activities for Bayer, BMS/Pfizer, Boehringer Ingelheim, Medtronic, and Novartis. TB reports consultant activities for Edwards Lifesciences. AB (Anne Bernard) reports consulting or speaker activities for BMS/Pfizer and Abbott. TC reports consulting or speaker activities for Edwards,
Acknowledgments
None.
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Cited by (2)
Predicting 5-Year Clinical Outcomes After Transcatheter or Surgical Aortic Valve Replacement (a Risk Score from the SURTAVI Trial)
2023, American Journal of CardiologySex, Antithrombotics, and Outcomes After TAVR: Is There More Difference Within Sexes or Between Them?
2023, JACC: Cardiovascular Interventions
Funding: None.