Coronary Disease Association With ADAMTS7 Is Due to Protease Activity

Circ Res. 2021 Aug 6;129(4):458-470. doi: 10.1161/CIRCRESAHA.121.319163. Epub 2021 Jun 28.

Taiji Mizoguchi^{1

2}, Bryan T MacDonald¹, Bidur Bhandary¹, Nicholas R Popp¹, Dylan Laprise³, Alessandro Arduini¹, Daniel Lai¹, Qiuyu Martin Zhu^{1

4}, Yi Xing³, Virendar K Kaushik³, Sekar Kathiresan^#^{1

2

4}, Patrick T Ellinor^#^{1

5}

¹ Cardiovascular Disease Initiative (T.M., B.T.M., B.B., N.R.P., A.A., D.L., Q.M.Z., S.K., P.T.E.), Broad Institute of MIT and Harvard, Cambridge, MA.
² Now with Verve Therapeutics, Cambridge, MA, USA (T.M., S.K.).
³ Center for the Development of Therapeutics (D.L., Y.X., V.K.K.), Broad Institute of MIT and Harvard, Cambridge, MA.
⁴ Center for Genomic Medicine (Q.M.Z., S.K.), Massachusetts General Hospital, Boston.
⁵ Cardiovascular Research Center (P.T.E.), Massachusetts General Hospital, Boston.

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: atherosclerosis; coronary artery disease; phenotype; protease; wound healing.