Smooth Muscle Overexpression of PGC1α Attenuates Atherosclerosis in Rabbits

Circ Res. 2021 Aug 6;129(4):e72-e86. doi: 10.1161/CIRCRESAHA.120.317705. Epub 2021 Jun 24.

¹ Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), Institute of Artificial Intelligence Biomedicine, School of Life Sciences, Nanjing University, Jiangsu, China (Z.W., Y.T., J.X., H.W., Y.S., L.C., Jing Li, Y.Z., X.C., D.W., C.-Y.Z., X.J.).
² Thoracic and Cardiovascular Surgery, Nanjing Drum Tower Hospital, China (H.C., Y.X.).
³ Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, China (Q.J., Jutang Li).
⁴ Institute of Cardiovascular Science, Peking University, Beijing, China (G.L.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: atherosclerosis; metabolism; rabbits; smooth muscle myocytes.

Animals
Atherosclerosis / genetics
Atherosclerosis / metabolism*
Cell Adhesion Molecules / metabolism
Cellular Senescence
Cytokines / metabolism
ErbB Receptors / metabolism
MAP Kinase Signaling System
Matrix Metalloproteinases / metabolism
Muscle, Smooth, Vascular / metabolism*
PPAR gamma / metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism*
Rabbits
Reactive Oxygen Species / metabolism
Serum Response Factor / metabolism
Up-Regulation
ets-Domain Protein Elk-1 / metabolism