KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

Circ Res. 2021 Aug 6;129(4):e87-e100. doi: 10.1161/CIRCRESAHA.120.318690. Epub 2021 Jun 23.

Juan Huang^#^{1

2

3}, Yujie Pu^#^{1

2}, Hongsong Zhang^#⁴, Liping Xie⁵, Lei He^{1

2}, Cheng-Lin Zhang^{1

2}, Chak Kwong Cheng^{1

2}, Yingsong Huo⁶, Song Wan⁷, Shaoliang Chen⁴, Yuhong Huang^{1

2}, Chi Wai Lau^{1

2}, Li Wang^{1

2}, Yin Xia², Yu Huang^{1

2}, Jiang-Yun Luo^{1

2}

¹ Heart and Vascular Institute, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences (J.H., Y.P., L.H., C.-L.Z., C.K.C., Yuhong Huang, C.W.L., L.W., Yu Huang, J.-Y.L.), Chinese University of Hong Kong, China.
² School of Biomedical Sciences (J.H., Y.P., L.H., C.-L.Z., C.K.C., Yuhong Huang, C.W.L., L.W., Y.X., Yu Huang, J.-Y.L.), Chinese University of Hong Kong, China.
³ Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, China (J.H.).
⁴ Department of Cardiology, Nanjing First Hospital (H.Z., S.C.), Nanjing Medical University, China.
⁵ Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine (L.X.), Nanjing Medical University, China.
⁶ Department of Radiology, Nanjing First Hospital (Y.H.), Nanjing Medical University, China.
⁷ Department of Surgery (S.W.), Chinese University of Hong Kong, China.

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: endothelial cells; vascular calcification.