Incidence, Predictors, and Prognostic Impact of Immediate Improvement in Left Ventricular Systolic Function After Transcatheter Aortic Valve Implantation
Section snippets
Methods
The ASAN-TAVR registry is a prospective registry that includes “all-comers” consecutive patients with symptomatic severe AS who undergo TAVI at Asan Medical Center (Seoul, Republic of Korea).6, 7, 8 The traditional surgical risk score was calculated according to the Society of Thoracic Surgeons (STS) score and the Logistic European System for Cardiac Operative Risk Evaluation (EuroSCORE).
TAVI was performed under general anesthesia or monitored anesthesia care using standard methods. The
Results
Between March 2010 to December 2019, 700 patients with severe symptomatic AS who underwent TAVI were enrolled in the ASAN-TAVR registry, of which 6 were excluded from the current analysis for the following reasons: Two patients died before post-TAVI echocardiography, 2 underwent conversion to SAVR, and 2 did not receive post-TAVI echo during the index hospitalization. Therefore, 694 patients were included in the final analysis.
Among the 694 eligible patients, 160 (23.1%) demonstrated immediate
Discussion
This study examined the incidence, predictors, and prognostic impact of immediate LVEF recovery in “real-world” patients with severe AS undergoing TAVI; the main findings were as follows: (1) Nearly one-fourth of patients undergoing TAVI had immediate LVEF improvement post-TAVI during the index hospitalization, and this pattern was more prominent in patients with severe LV dysfunction at baseline; (2) absence of hypertension and increased baseline LV mass index were independent predictors of
Author Contributions
Yeong Jin Jeong: Formal analysis, Writing – Original Draft, Review & Editing
Jung-Min Ahn: Conceptualization, Resources, Project administration
Do-Yoon Kang: Resources, Investigation
Hanbit Park: Resources, Investigation
Euihong Ko: Resources, Investigation
Ho Jin Kim: Resources, Investigation
Joon Bum Kim: Resources, Investigation
Suk Jung Choo: Resources, Investigation
Seung-Ah Lee: Resources, Investigation,
Seung-Jung Park: Conceptualization, Resources, Investigation, Methodology, Supervision,
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Acknowledgement: This study was partly supported by the CardioVascular Research Foundation (Seoul, Korea). The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.
Clinical Trial Registration: http://ClinicalTrials.gov (identifier: NCT03298178)