Multimodality Imaging Assessment of Myocardial Fibrosis

JACC Cardiovasc Imaging. 2021 Dec;14(12):2457-2469. doi: 10.1016/j.jcmg.2021.01.027. Epub 2021 May 19.

Abstract

Myocardial fibrosis, seen in ischemic and nonischemic cardiomyopathies, is associated with adverse cardiac outcomes. Noninvasive imaging plays a key role in early identification and quantification of myocardial fibrosis with the use of an expanding array of techniques including cardiac magnetic resonance, computed tomography, and nuclear imaging. This review discusses currently available noninvasive imaging techniques, provides insights into their strengths and limitations, and examines novel developments that will affect the future of noninvasive imaging of myocardial fibrosis.

Keywords: T1 mapping; cardiac computed tomography; cardiac magnetic resonance; late gadolinium enhancement; myocardial fibrosis; nuclear imaging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiomyopathies* / diagnostic imaging
  • Cardiomyopathies* / pathology
  • Contrast Media
  • Fibrosis
  • Humans
  • Magnetic Resonance Imaging / methods
  • Myocardium* / pathology
  • Predictive Value of Tests

Substances

  • Contrast Media