Innate immunity in lung transplantation

J Heart Lung Transplant. 2021 Jul;40(7):562-568. doi: 10.1016/j.healun.2021.03.017. Epub 2021 Mar 26.

Abstract

Innate immune pathways early after pulmonary transplantation have been shown to cause primary graft dysfunction (PGD) and also predispose to late graft failure. Recent studies in animal models have elucidated critical mechanisms governing such innate immune responses. Here, we discuss pathways of inflammatory cell death, triggers for sterile and infectious inflammation, and signaling cascades that mediate lung injury early after transplantation. These studies highlight potential avenues for lung-specific therapies early following lung transplantation to dampen innate immune responses and improve outcomes.

Keywords: cell death; damage-associated molecular patterns; graft rejection; innate immunity; lung transplantation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Graft Rejection / immunology*
  • Humans
  • Immunity, Innate*
  • Lung Transplantation*
  • Primary Graft Dysfunction / immunology*