JACC Focus Seminar: Precision Medicine: From Genes to Phenotypes in Cardiovascular Health and DiseaseJACC Focus SeminarPrecision Medicine in Catecholaminergic Polymorphic Ventricular Tachycardia: JACC Focus Seminar 5/5
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Key Words
cardiovascular
catecholaminergic polymorphic ventricular tachycardia precision medicine
genetics
Abbreviations and Acronyms
AAV
adeno-associated virus
BB
beta-blockers
bVT
bidirectional ventricular tachycardia
CALM
calmodulin
CaMKII
Ca2+/calmodulin-dependent protein kinase II
Cas9
CRISPR-associated protein 9
CASQ2
calsequestrin 2
CPVT
catecholaminergic polymorphic ventricular tachycardia
CRISPR
clustered regularly interspaced short palindromic repeat
DAD
delayed afterdepolarization
ECG
electrocardiogram
EST
exercise stress test
hiPSC-CM
human induced pluripotent stem cell-derived cardiomyocytes
HRC
histidine-rich Ca2+ binding protein
ICD
implantable cardioverter-defibrillator
jSR
junctional sarcoplasmic reticulum
PVC
premature ventricular contraction
pVT
polymorphic ventricular tachycardia
RYR2
ryanodine receptor 2
SR
sarcoplasmic reticulum
TA
triggered activity
TECRL
trans-2,3-enoyl-CoA reductase-like
TRDN
triadin
VA
ventricular arrhythmias
VF
ventricular fibrillation
VT
ventricular tachycardia
WT
wild-type
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David Lanfear, MD, served as Guest Associate Editor for this paper. Javed Butler, MD, MPH, MBA, served as Guest Editor-in-Chief for this paper.
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© 2021 by the American College of Cardiology Foundation. Published by Elsevier.