Impact of Percutaneous Coronary Intervention on Outcomes in Patients With Heart Failure: JACC State-of-the-Art Review

Puja B Parikh; Deepak L Bhatt; Varun Bhasin; Stefan D Anker; Hal A Skopicki; Bimmer E Claessen; Gregg C Fonarow; Adrian F Hernandez; Roxana Mehran; Mark C Petrie; Javed Butler

doi:10.1016/j.jacc.2021.03.310

Impact of Percutaneous Coronary Intervention on Outcomes in Patients With Heart Failure: JACC State-of-the-Art Review

J Am Coll Cardiol. 2021 May 18;77(19):2432-2447. doi: 10.1016/j.jacc.2021.03.310.

Authors

Affiliations

¹ Department of Medicine, Stony Brook Renaissance School of Medicine, Stony Brook, New York, USA. Electronic address: puja.parikh@stonybrookmedicine.edu.
² Department of Medicine, Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School, Boston, Massachusetts, USA.
³ Department of Medicine, Stony Brook Renaissance School of Medicine, Stony Brook, New York, USA.
⁴ Department of Cardiology (CVK) and Berlin Institute of Health Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Charité-Universitätsmedizin Berlin, Germany.
⁵ Department of Cardiology, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
⁶ Ahmanson-UCLA Cardiomyopathy Center, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.
⁷ Department of Medicine and Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
⁸ Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA.
⁹ BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
¹⁰ Department of Medicine, University of Mississippi, Jackson, Mississippi, USA. Electronic address: jbutler4@umc.edu.

PMID: 33985688
DOI: 10.1016/j.jacc.2021.03.310

Abstract

Coronary artery disease (CAD) is highly prevalent in patients with heart failure (HF) and accounts for nearly two-thirds of cases. The use of percutaneous coronary intervention (PCI) in HF patients with CAD has markedly increased and has been suggested to be associated with improved outcomes in numerous observational studies. Randomized data comparing the impact of PCI with that of coronary artery bypass graft (CABG) or contemporary guideline-directed medical therapy alone on clinical outcomes and myocardial recovery in patients with HF are lacking. The purpose of this review is to describe the available evidence regarding the impact of PCI in acute HF (in the presence and absence of an acute coronary syndrome), chronic HF with reduced ejection fraction, and HF with preserved ejection fraction. Adequately-powered randomized clinical trials examining the outcomes with PCI in these distinct HF populations are warranted.

Keywords: coronary artery disease; coronary revascularization; ejection fraction; heart failure; percutaneous coronary intervention.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Coronary Artery Disease / complications
Coronary Artery Disease / surgery*
Heart Failure / complications*
Heart Failure / surgery
Humans
Percutaneous Coronary Intervention / methods*
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding