NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review

William M Oldham; Anna R Hemnes; Micheala A Aldred; John Barnard; Evan L Brittain; Stephen Y Chan; Feixiong Cheng; Michael H Cho; Ankit A Desai; Joe G N Garcia; Mark W Geraci; Susan D Ghiassian; Kathryn T Hall; Evelyn M Horn; Mohit Jain; Rachel S Kelly; Jane A Leopold; Sara Lindstrom; Brian D Modena; William C Nichols; Christopher J Rhodes; Wei Sun; Andrew J Sweatt; Rebecca R Vanderpool; Martin R Wilkins; Beth Wilmot; Roham T Zamanian; Joshua P Fessel; Neil R Aggarwal; Joseph Loscalzo; Lei Xiao

doi:10.1016/j.jacc.2021.02.056

NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review

J Am Coll Cardiol. 2021 Apr 27;77(16):2040-2052. doi: 10.1016/j.jacc.2021.02.056.

Authors

William M Oldham¹, Anna R Hemnes², Micheala A Aldred³, John Barnard⁴, Evan L Brittain², Stephen Y Chan⁵, Feixiong Cheng⁴, Michael H Cho⁶, Ankit A Desai³, Joe G N Garcia⁷, Mark W Geraci⁸, Susan D Ghiassian⁹, Kathryn T Hall⁶, Evelyn M Horn¹⁰, Mohit Jain¹¹, Rachel S Kelly⁶, Jane A Leopold⁶, Sara Lindstrom¹², Brian D Modena¹³, William C Nichols¹⁴, Christopher J Rhodes¹⁵, Wei Sun⁵, Andrew J Sweatt¹⁶, Rebecca R Vanderpool⁸, Martin R Wilkins¹⁵, Beth Wilmot¹⁷, Roham T Zamanian¹⁶, Joshua P Fessel¹⁸, Neil R Aggarwal¹⁸, Joseph Loscalzo⁶, Lei Xiao¹⁹

Affiliations

¹ Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address: woldham@bwh.harvard.edu.
² Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³ Indiana University School of Medicine, Indianapolis, Indiana, USA.
⁴ Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
⁵ Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
⁶ Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁷ University of Arizona, Tucson, Arizona, USA.
⁸ Department of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
⁹ Scipher Medicine, Inc., Waltham, Massachusetts, USA.
¹⁰ Weill Cornell Medical Center, New York, New York, USA.
¹¹ University of California at San Diego, San Diego, California, USA.
¹² University of Washington, Seattle, Washington, USA.
¹³ National Jewish Health, Denver, Colorado, USA.
¹⁴ Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
¹⁵ Imperial College London, London, United Kingdom.
¹⁶ Stanford University School of Medicine, Stanford, California, USA.
¹⁷ Division of Geriatrics and Clinical Gerontology, National Institute on Aging and the School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
¹⁸ Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
¹⁹ Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: lei.xiao@nih.gov.

Abstract

The National Heart, Lung, and Blood Institute and the Cardiovascular Medical Research and Education Fund held a workshop on the application of pulmonary vascular disease omics data to the understanding, prevention, and treatment of pulmonary vascular disease. Experts in pulmonary vascular disease, omics, and data analytics met to identify knowledge gaps and formulate ideas for future research priorities in pulmonary vascular disease in line with National Heart, Lung, and Blood Institute Strategic Vision goals. The group identified opportunities to develop analytic approaches to multiomic datasets, to identify molecular pathways in pulmonary vascular disease pathobiology, and to link novel phenotypes to meaningful clinical outcomes. The committee suggested support for interdisciplinary research teams to develop and validate analytic methods, a national effort to coordinate biosamples and data, a consortium of preclinical investigators to expedite target evaluation and drug development, longitudinal assessment of molecular biomarkers in clinical trials, and a task force to develop a master clinical trials protocol for pulmonary vascular disease.

Keywords: drug repurposing; integrative omics; master clinical trial protocol; precision medicine; pulmonary hypertension; systems biology.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomedical Research / trends*
Cardiovascular Diseases / classification
Cardiovascular Diseases / diagnosis
Cardiovascular Diseases / epidemiology
Computational Biology / methods
Computational Biology / trends
Education / trends*
Humans
Lung Diseases / classification*
Lung Diseases / diagnosis
Lung Diseases / epidemiology
National Heart, Lung, and Blood Institute (U.S.) / trends*
Pulmonary Circulation / physiology
Research Report / trends*
Review Literature as Topic
United States / epidemiology
Vascular Diseases / classification*
Vascular Diseases / diagnosis
Vascular Diseases / epidemiology

Abstract

Publication types

MeSH terms

Grants and funding