A Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e314-e324. doi: 10.1161/ATVBAHA.120.315428. Epub 2021 Apr 22.

Michael N Sayegh^{1

2}, Kimberly A Cooney¹, Woojin M Han^{3

4}, Lanfang Wang¹, Frederick Strobel⁵, Laura M Hansen¹, Andrés J García^{3

4}, Rebecca D Levit¹

¹ Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA (M.N.S., K.A.C., L.W., L.M.H., R.D.L.).
² Wallace H. Coulter Department of Biomedical Engineering (M.N.S.), Georgia Institute of Technology, Atlanta.
³ George W. Woodruff School of Mechanical Engineering (W.M.H., A.J.G.), Georgia Institute of Technology, Atlanta.
⁴ Parker H. Petit Institute for Bioengineering and Biosciences (W.M.H., A.J.G.), Georgia Institute of Technology, Atlanta.
⁵ Department of Chemistry, Emory University, Atlanta, GA (F.S.).

Abstract

[Figure: see text].

Keywords: 5'-nucleotidase; adenosine; hydrogel; perfusion; peripheral artery disease.