Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia

J Mol Cell Cardiol. 2021 Jul:156:105-113. doi: 10.1016/j.yjmcc.2021.04.002. Epub 2021 Apr 17.

Abstract

Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to malignant cardiac arrhythmias. Both defective mitochondrial function and abnormal intracellular Ca2+ homeostasis have been established as the key contributing factors in the pathophysiology and arrhythmogenesis in these conditions. This article reviews current advances in understanding of bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca2+ release and mitochondrial function, and how defects in crosstalk between these two organelles increase arrhythmic risk in cardiac disease.

Keywords: Calcium signaling; Cardiac arrhythmia; Mitochondria; Sarcoplasmic reticulum.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / drug therapy
  • Arrhythmias, Cardiac / etiology*
  • Arrhythmias, Cardiac / metabolism*
  • Arrhythmias, Cardiac / physiopathology
  • Biomarkers*
  • Calcium / metabolism
  • Calcium Signaling
  • Disease Susceptibility*
  • Energy Metabolism
  • Homeostasis
  • Humans
  • Mitochondria, Heart / drug effects
  • Mitochondria, Heart / metabolism*
  • Molecular Targeted Therapy
  • Oxidation-Reduction
  • Sarcoplasmic Reticulum / drug effects
  • Sarcoplasmic Reticulum / metabolism*
  • Signal Transduction* / drug effects

Substances

  • Biomarkers
  • Calcium