An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts

Circ Res. 2021 Jun 25;129(1):33-46. doi: 10.1161/CIRCRESAHA.121.319060. Epub 2021 Apr 15.

¹ Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
² Department of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
³ Division of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
⁴ Department of Physiology, Biophysics and Systems Biology (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
⁵ Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY (P.W., Y. Huang, D.D.H.).
⁶ Genomics Resources Core Facility (T.Z., J.X.), Weill Cornell Medicine, New York, NY.
⁷ Division of Regenerative Medicine, Ansary Stem Cell Institute (D.R., S.H.), Weill Cornell Medicine, New York, NY.
⁸ Department of Pathology and Laboratory Medicine (A.B.), Weill Cornell Medicine, New York, NY.
⁹ Graduate School of Biomedical Sciences (J.A.A.), Icahn School of Medicine at Mount Sinai, New York, NY.
¹⁰ Department of Population Health Sciences (Z.C.), Weill Cornell Medicine, New York, NY.

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: autopsy; drug evaluation, preclinical; inflammation; myocytes, cardiac; pyrimidines.