Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1956-1971. doi: 10.1161/ATVBAHA.121.315878. Epub 2021 Apr 15.

Authors

Jay Zhu¹, Stoyan Angelov², Ilkay Alp Yildirim^{2

3}, Hao Wei², Jie Hong Hu², Mark W Majesky^{4

5

6}, Frank V Brozovich⁷, Francis Kim², David A Dichek^{2

5}

Affiliations

¹ Surgery (J.Z.), University of Washington, Seattle.
² Departments of Medicine (S.A., I.A.Y., H.W., J.H.H., F.K., D.A.D.), University of Washington, Seattle.
³ Now with Istanbul University Faculty of Pharmacy, Department of Pharmacology, Istanbul, Turkey (I.A.Y.).
⁴ Pediatrics (M.W.M.), University of Washington, Seattle.
⁵ Laboratory Medicine and Pathology (M.W.M., D.A.D.), University of Washington, Seattle.
⁶ The Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, WA (M.W.M.).
⁷ Department of Medicine, Mayo School of Medicine, Rochester, MN (F.V.B.).

Abstract

[Figure: see text].

Keywords: aorta; endothelium; mice; myography; transforming growth factor beta.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Aorta / metabolism
Aorta / pathology
Aorta / physiopathology
Aortic Aneurysm / genetics
Aortic Aneurysm / metabolism*
Aortic Aneurysm / pathology
Aortic Aneurysm / physiopathology
Cell Adhesion Molecules / metabolism
Dilatation, Pathologic
Endothelium, Vascular / metabolism*
Endothelium, Vascular / pathology
Endothelium, Vascular / physiopathology
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microfilament Proteins / metabolism
Muscle, Smooth, Vascular / metabolism*
Muscle, Smooth, Vascular / pathology
Muscle, Smooth, Vascular / physiopathology
Myosin Heavy Chains / genetics
Myosin Heavy Chains / metabolism
Nitric Oxide / metabolism
Nitric Oxide Synthase Type III / metabolism
Phosphoproteins / metabolism
Phosphorylation
Receptor, Transforming Growth Factor-beta Type II / deficiency*
Receptor, Transforming Growth Factor-beta Type II / genetics
Signal Transduction
Transforming Growth Factor beta / metabolism*
Vasoconstriction*

Substances

Cell Adhesion Molecules
Microfilament Proteins
Phosphoproteins
Transforming Growth Factor beta
myosin 11, mouse
vasodilator-stimulated phosphoprotein
Nitric Oxide
Nitric Oxide Synthase Type III
Nos3 protein, mouse
Receptor, Transforming Growth Factor-beta Type II
Tgfbr2 protein, mouse
Myosin Heavy Chains

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