Carbon Monoxide Suppresses Neointima Formation in Transplant Arteriosclerosis by Inhibiting Vascular Progenitor Cell Differentiation

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1915-1927. doi: 10.1161/ATVBAHA.120.315558. Epub 2021 Apr 15.

Abstract

[Figure: see text].

Keywords: bone marrow; carbon monoxide; heme oxygenase-1; neointima; platelet-derived growth factor receptor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Aorta, Thoracic / enzymology
  • Aorta, Thoracic / pathology
  • Aorta, Thoracic / transplantation*
  • Arteriosclerosis / enzymology
  • Arteriosclerosis / genetics
  • Arteriosclerosis / pathology
  • Arteriosclerosis / prevention & control*
  • Bone Marrow Transplantation
  • Carbon Monoxide / pharmacology*
  • Cell Differentiation / drug effects*
  • Cells, Cultured
  • Disease Models, Animal
  • Heme Oxygenase-1 / genetics
  • Heme Oxygenase-1 / metabolism
  • Kinetics
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Smooth, Vascular / drug effects*
  • Muscle, Smooth, Vascular / enzymology
  • Muscle, Smooth, Vascular / pathology
  • Myocytes, Smooth Muscle / drug effects*
  • Myocytes, Smooth Muscle / enzymology
  • Myocytes, Smooth Muscle / pathology
  • Neointima*
  • Receptor, Platelet-Derived Growth Factor beta / metabolism
  • Stem Cells / drug effects*
  • Stem Cells / enzymology
  • Stem Cells / pathology
  • Transplantation Chimera
  • Vascular Remodeling / drug effects

Substances

  • Membrane Proteins
  • Carbon Monoxide
  • Heme Oxygenase-1
  • Hmox1 protein, mouse
  • Receptor, Platelet-Derived Growth Factor beta