Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes

Circ Res. 2021 Jun 25;129(1):e1-e20. doi: 10.1161/CIRCRESAHA.119.316386. Epub 2021 Apr 14.

Authors

Pietro Mesirca^#¹, Shu Nakao^#^{2

3}, Sarah Dalgas Nissen^#⁴, Gabriella Forte², Cali Anderson², Tariq Trussell², Jue Li², Charlotte Cox², Min Zi², Sunil Logantha^{2

5}, Sana Yaar², Helena Cartensen⁴, Isabelle Bidaud¹, Luke Stuart², Luca Soattin, Gwilym M Morris², Paula A da Costa Martins⁶, Elizabeth J Cartwright², Delvac Oceandy², Matteo E Mangoni¹, Thomas Jespersen⁷, Rikke Buhl⁴, Halina Dobrzynski⁸, Mark R Boyett^{2

7}, Alicia D'Souza²

Affiliations

¹ IGF, Université de Montpellier, CNRS, INSERM, France (P.M., I.B., M.E.M.).
² Division of Cardiovascular Sciences, University of Manchester, United Kingdom (S.N., G.F., C.A., T.T., J.L., C.C., M.Z., S.L., S.Y., L. Stuart, L. Soattin, G.M.M., E.J.C., D.O., H.D., M.R.B., A.D.).
³ Department of Biomedical Sciences, Ritsumeikan University, Japan (S.N.).
⁴ Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences (S.D.N., H.C., R.B.), University of Copenhagen, Denmark.
⁵ Liverpool Centre for Cardiovascular Sciences, University of Liverpool, United Kingdom (S.L.).
⁶ Department of Cardiology, Maastricht University, the Netherlands (P.A.d.C.M.).
⁷ Department of Biomedical Sciences (T.J., M.R.B.), University of Copenhagen, Denmark.
⁸ Department of Anatomy, Jagiellonian University Medical College, Poland (H.D.).

^# Contributed equally.

PMID: 33849278
DOI: 10.1161/CIRCRESAHA.119.316386

Abstract

[Figure: see text].

Keywords: atrioventricular block; cardiac electrophysiology; exercise; ion channels; microRNAs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials*
Animals
Atrioventricular Block / chemically induced
Atrioventricular Block / diagnosis
Atrioventricular Block / metabolism*
Atrioventricular Block / physiopathology
Atrioventricular Node / metabolism*
Atrioventricular Node / physiopathology
Atropine
Biopsy
Calcium Channels, L-Type / genetics
Calcium Channels, L-Type / metabolism*
Disease Models, Animal
Electrocardiography
Heart Rate*
Horses
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism*
Male
Mice
Mice, Inbred C57BL
MicroRNAs / genetics
MicroRNAs / metabolism
Myocytes, Cardiac / metabolism*
Physical Conditioning, Animal
Physical Endurance*
Propranolol
Swimming
Transcription, Genetic

Substances

Calcium Channels, L-Type
Hcn4 protein, mouse
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
L-type calcium channel alpha(1C)
MIRN432 microRNA, mouse
MicroRNAs
Mirn211 microRNA, mouse
Atropine
Propranolol

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