Local Action of Neprilysin Exacerbates Pressure Overload Induced Cardiac Remodeling

Hypertension. 2021 Jun;77(6):1931-1939. doi: 10.1161/HYPERTENSIONAHA.120.16445. Epub 2021 Apr 12.

Authors

Hitoshi Nakagawa¹, Takuya Kumazawa¹, Kenji Onoue¹, Yasuki Nakada¹, Tomoya Nakano¹, Satomi Ishihara¹, Naoto Minamino², Hiroshi Hosoda³, Nobuhisa Iwata⁴, Tomoya Ueda¹, Ayako Seno¹, Taku Nishida¹, Tsunenari Soeda¹, Satoshi Okayama¹, Makoto Watanabe¹, Rika Kawakami¹, Yoshihiko Saito¹

Affiliations

¹ Cardiovascular Medicine, Nara Medical University, Nara, Japan (H.N., T.K., K.O., Y.N., T. Nakano, S.I., T.U., A.S., T. Nishida, T.S., S.O., M.W., R.K., Y.S.).
² Omics Research Center (N.M.), National Cerebral and Cardiovascular Center, Suita, Japan.
³ Departments of Regenerative Medicine and Tissue Engineering (H.H.), National Cerebral and Cardiovascular Center, Suita, Japan.
⁴ Department of Genome-based Drug Discovery, Nagasaki University, Japan (N.I.).

PMID: 33840200
DOI: 10.1161/HYPERTENSIONAHA.120.16445

Abstract

[Figure: see text].

Keywords: guanosine monophosphate; heart failure; natriuretic peptides; neprilysin; plasma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Atrial Natriuretic Factor / blood*
Blood Pressure / physiology*
Cyclic GMP / blood
Cyclic GMP / metabolism
Heart Failure / genetics
Heart Failure / metabolism
Heart Failure / physiopathology
Mice
Mice, Transgenic
Myocardium / metabolism*
Neprilysin / genetics
Neprilysin / metabolism*
Ventricular Remodeling / physiology*

Substances

Atrial Natriuretic Factor
Neprilysin
Cyclic GMP