Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity

Hypertension. 2021 Jul;78(1):138-150. doi: 10.1161/HYPERTENSIONAHA.120.16377. Epub 2021 Apr 12.

Asako Kumagai^{1

2

3}, Satoru Takeda², Eisei Sohara⁴, Shinichi Uchida⁴, Hiroshi Iijima⁵, Astuo Itakura², Daisuke Koya^{3

6}, Keizo Kanasaki^{1

6}

¹ Faculty of Medicine, Internal Medicine I, Shimane University, Izumo, Japan (A.K., K.K.).
² Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Bunkyo, Tokyo, Japan (A.K., S.T., A.I.).
³ Department of Diabetology and Endocrinology (A.K., D.K.), Kanazawa Medical University, Ishikawa, Japan.
⁴ Department of Nephrology, Tokyo Medical and Dental University, Yushima, Bunkyo, Japan (E.S., S.U.).
⁵ School of Pharmacy, Nihon University, Chiba, Japan (H.I.).
⁶ Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute (D.K., K.K.), Kanazawa Medical University, Ishikawa, Japan.

Abstract

[Figure: see text].

Keywords: 2-methoxyestradiol; blood pressure; magnesium; mice; sodium chloride.