Role of genetics in atrial fibrillation management

Michiel Rienstra; Joylene E Siland; Patrick T Ellinor

doi:10.1093/europace/euaa366

Role of genetics in atrial fibrillation management

Europace. 2021 Apr 10;23(23 Suppl 2):ii4-ii8. doi: 10.1093/europace/euaa366.

Authors

Michiel Rienstra¹, Joylene E Siland¹, Patrick T Ellinor^{2

3

4}

Affiliations

¹ Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
² Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
³ Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
⁴ Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.

Abstract

Atrial fibrillation (AF) management has significantly improved during the career of professor Crijns. Research was implemented into guidelines and clinical practice. However, despite advances in AF management, large differences between individual treatment responses still exist and the mechanisms underlying initiation and perpetuation of AF are not completely understood. International collaborations have revealed the genetic contribution to AF and steps towards improving AF management are being made. In this short review, the most important paradigms shifts in the field of AF genetics are recognized and the future role of genetics in personalized management of AF is discussed.

Keywords: Atrial fibrillation; Genetics; Risk factors; Treatment.

MeSH terms

Atrial Fibrillation* / diagnosis
Atrial Fibrillation* / genetics
Atrial Fibrillation* / therapy
Humans

Grants and funding

K24 HL105780/HL/NHLBI NIH HHS/United States