Over-Expression of Intestinal Alkaline Phosphatase Attenuates Atherosclerosis

Circ Res. 2021 May 28;128(11):1646-1659. doi: 10.1161/CIRCRESAHA.120.317144. Epub 2021 Apr 9.

Abstract

[Figure: see text].

Keywords: atherosclerosis; diet, Western; inflammation; lipids; liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaline Phosphatase / blood*
  • Animals
  • Atherosclerosis / etiology
  • Atherosclerosis / metabolism*
  • Atherosclerosis / pathology
  • CD36 Antigens / metabolism
  • Carrier Proteins / metabolism
  • Colon / anatomy & histology
  • Colon / metabolism
  • Diet, Atherogenic / adverse effects
  • Fatty Acid Transport Proteins / metabolism
  • Fatty Acid-Binding Proteins / metabolism
  • GPI-Linked Proteins / blood
  • Humans
  • Intestinal Absorption*
  • Intestinal Mucosa
  • Lipid Metabolism
  • Lipids / analysis
  • Lipids / blood
  • Lipopolysaccharides / blood*
  • Liver / metabolism
  • Membrane Transport Proteins / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Weight Loss

Substances

  • CD36 Antigens
  • Carrier Proteins
  • FABP1 protein, human
  • FABP2 protein, human
  • Fatty Acid Transport Proteins
  • Fatty Acid-Binding Proteins
  • GPI-Linked Proteins
  • Lipids
  • Lipopolysaccharides
  • Membrane Transport Proteins
  • NPC1L1 protein, human
  • SLC27A4 protein, human
  • sterol carrier proteins
  • ALPI protein, human
  • Alkaline Phosphatase