Fetal Programming by Methyl Donor Deficiency Produces Pathological Remodeling of the Ascending Aorta

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1928-1941. doi: 10.1161/ATVBAHA.120.315587. Epub 2021 Apr 8.

Abstract

[Figure: see text].

Keywords: aorta; blood pressure; extracellular matrix; homocysteine; vinculin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Nutritional Physiological Phenomena
  • Animals
  • Aorta / metabolism
  • Aorta / pathology*
  • Aortic Diseases / etiology*
  • Aortic Diseases / genetics
  • Aortic Diseases / metabolism
  • Aortic Diseases / pathology
  • Disease Models, Animal
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / metabolism
  • Female
  • Fetal Development*
  • Folic Acid Deficiency / complications*
  • Folic Acid Deficiency / genetics
  • Folic Acid Deficiency / metabolism
  • Gene Expression Regulation, Developmental
  • Gestational Age
  • Homocysteine / metabolism
  • Maternal Nutritional Physiological Phenomena
  • Peptide Hydrolases / metabolism
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Rats
  • Rats, Wistar
  • Vascular Remodeling*
  • Vitamin B 12 Deficiency / complications*
  • Vitamin B 12 Deficiency / genetics
  • Vitamin B 12 Deficiency / metabolism

Substances

  • Extracellular Matrix Proteins
  • Homocysteine
  • Peptide Hydrolases