Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):2049-2062. doi: 10.1161/ATVBAHA.121.316111. Epub 2021 Apr 8.

Abstract

[Figure: see text].

Keywords: heart ventricles; mitral valve; mitral valve insufficiency; myocardial infarction; transforming growth factor beta.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 4 / metabolism*
  • Cells, Cultured
  • Disease Models, Animal
  • Female
  • Gene Regulatory Networks
  • Leukocyte Common Antigens / genetics
  • Leukocyte Common Antigens / metabolism*
  • Male
  • Mitral Valve / drug effects*
  • Mitral Valve / metabolism
  • Mitral Valve / pathology
  • Mitral Valve / physiopathology
  • Mitral Valve Insufficiency / genetics
  • Mitral Valve Insufficiency / metabolism*
  • Mitral Valve Insufficiency / pathology
  • Mitral Valve Insufficiency / physiopathology
  • Myocardial Infarction / genetics
  • Myocardial Infarction / metabolism*
  • Myocardial Infarction / pathology
  • Myocardial Infarction / physiopathology
  • Protein Interaction Maps
  • Sheep, Domestic
  • Signal Transduction
  • Transcriptome
  • Transforming Growth Factor beta1 / pharmacology*
  • Ventricular Function, Left
  • Ventricular Remodeling

Substances

  • Bone Morphogenetic Protein 4
  • Transforming Growth Factor beta1
  • Leukocyte Common Antigens