Major Reservoir for Heparin-Releasable TFPIα (Tissue Factor Pathway Inhibitor α) Is Extracellular Matrix

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1942-1955. doi: 10.1161/ATVBAHA.120.315728. Epub 2021 Apr 8.

Abstract

[Figure: see text].

Keywords: blood coagulation inhibitor; glycosaminoglycans; glypican; heparin; thromboplastin; thrombospondin; vascular endothelial growth factor.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Binding Sites
  • Binding, Competitive
  • Cell Adhesion Molecules / metabolism
  • Cell Line
  • Endothelial Cells / drug effects
  • Endothelial Cells / metabolism*
  • Extracellular Matrix / drug effects
  • Extracellular Matrix / metabolism*
  • Glypicans / metabolism
  • Heparin / pharmacology
  • Human Umbilical Vein Endothelial Cells / drug effects
  • Human Umbilical Vein Endothelial Cells / metabolism
  • Humans
  • Kalinin
  • Kidney / blood supply*
  • Lipoproteins / metabolism*
  • Protein Binding
  • Protein Isoforms
  • Proteoglycans / metabolism*
  • Syndecan-4 / metabolism
  • Thrombospondins / metabolism

Substances

  • Cell Adhesion Molecules
  • GPC1 protein, human
  • Glypicans
  • Lipoproteins
  • Protein Isoforms
  • Proteoglycans
  • SDC4 protein, human
  • Syndecan-4
  • Thrombospondins
  • lipoprotein-associated coagulation inhibitor
  • Heparin