Per-Particle Triglyceride-Rich Lipoproteins Imply Higher Myocardial Infarction Risk Than Low-Density Lipoproteins: Copenhagen General Population Study

Mia Ø Johansen; Signe Vedel-Krogh; Sune F Nielsen; Shoaib Afzal; George Davey Smith; Børge G Nordestgaard

doi:10.1161/ATVBAHA.120.315639

Per-Particle Triglyceride-Rich Lipoproteins Imply Higher Myocardial Infarction Risk Than Low-Density Lipoproteins: Copenhagen General Population Study

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):2063-2075. doi: 10.1161/ATVBAHA.120.315639. Epub 2021 Apr 8.

Authors

Mia Ø Johansen^{1

2

3}, Signe Vedel-Krogh^{1

2

3}, Sune F Nielsen^{1

2

3}, Shoaib Afzal^{1

2

3}, George Davey Smith^{4

5}, Børge G Nordestgaard^{1

2

3}

Affiliations

¹ Department of Clinical Biochemistry (M.O.J., S.V.-K., S.F.N., S.A., B.G.N.), Herlev and Gentofte Hospital, CopenhagenUniversity Hospital, Denmark.
² The Copenhagen General Population Study (M.O.J., S.V.-K., S.F.N., S.A., B.G.N.), Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark.
³ Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (M.O.J., S.V.-K., S.F.N., S.A., B.G.N.).
⁴ MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, United Kingdom (G.D.S.).
⁵ Population Health Sciences, Bristol Medical School, University of Bristol, United Kingdom (G.D.S.).

PMID: 33827253
DOI: 10.1161/ATVBAHA.120.315639

Abstract

[Figure: see text].

Keywords: apolipoproteins; epidemiology; lipids; metabolomics; stroke.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Apolipoprotein B-100 / blood
Biomarkers / blood
Denmark / epidemiology
Dyslipidemias / blood*
Dyslipidemias / diagnosis
Dyslipidemias / epidemiology
Female
Heart Disease Risk Factors
Humans
Lipoproteins, IDL / blood
Lipoproteins, LDL / blood*
Lipoproteins, VLDL / blood
Magnetic Resonance Spectroscopy
Male
Middle Aged
Myocardial Infarction / blood*
Myocardial Infarction / diagnosis
Myocardial Infarction / epidemiology
Particle Size
Prognosis
Risk Assessment
Time Factors
Triglycerides / blood*
Young Adult

Substances

APOB protein, human
Apolipoprotein B-100
Biomarkers
Lipoproteins, IDL
Lipoproteins, LDL
Lipoproteins, VLDL
Triglycerides
low density lipoprotein triglyceride
very low density lipoprotein triglyceride

Grants and funding

MC_UU_00011/1/MRC_/Medical Research Council/United Kingdom