Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1987-2005. doi: 10.1161/ATVBAHA.121.316153. Epub 2021 Apr 8.

Abstract

[Figure: see text].

Keywords: cell adhesion molecules; cytokines; inflammation; thromboplastin; thrombosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cytokines / metabolism
  • Disease Models, Animal
  • Endotoxins
  • Extracellular Traps / metabolism
  • Female
  • Human Umbilical Vein Endothelial Cells / metabolism*
  • Human Umbilical Vein Endothelial Cells / pathology
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Inflammation Mediators / metabolism*
  • Lung / metabolism*
  • Lung / microbiology
  • Lung / pathology
  • Male
  • Mice
  • Mice, Knockout
  • Pneumococcal Infections / genetics
  • Pneumococcal Infections / metabolism*
  • Pneumococcal Infections / microbiology
  • Pneumococcal Infections / pathology
  • Pneumonia, Bacterial / genetics
  • Pneumonia, Bacterial / metabolism*
  • Pneumonia, Bacterial / microbiology
  • Pneumonia, Bacterial / pathology
  • Signal Transduction
  • Thrombin / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Cytokines
  • Endotoxins
  • GAB2 protein, human
  • Gab2 protein, mouse
  • Inflammation Mediators
  • endotoxin, Escherichia coli
  • Thrombin