Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

Circ Res. 2021 May 28;128(11):1663-1678. doi: 10.1161/CIRCRESAHA.120.317791. Epub 2021 Apr 7.

Abstract

[Figure: see text].

Keywords: fibroblasts; fibrosis; mice; myocardial infarction; salinomycin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / pharmacology
  • Animals
  • Antifibrotic Agents / pharmacology*
  • Cardiomegaly / prevention & control*
  • Cell Survival / drug effects
  • Disease Models, Animal
  • Extracellular Matrix*
  • Fibrosis
  • Gene Expression
  • Heart Failure / drug therapy
  • Heart Failure / pathology
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myocardial Infarction / pathology
  • Myocardium / pathology*
  • Myofibroblasts / drug effects*
  • NIH 3T3 Cells
  • Pyrans / isolation & purification
  • Pyrans / pharmacology*
  • Ventricular Remodeling / drug effects
  • p38 Mitogen-Activated Protein Kinases / drug effects
  • p38 Mitogen-Activated Protein Kinases / metabolism
  • rho-Associated Kinases / drug effects
  • rho-Associated Kinases / metabolism

Substances

  • Antifibrotic Agents
  • Pyrans
  • Angiotensin II
  • salinomycin
  • rho-Associated Kinases
  • p38 Mitogen-Activated Protein Kinases