In imaging-selected ischemic stroke with unknown onset, alteplase increases favorable outcomes and death at 90 d

Michael D Hill

doi:10.7326/ACPJ202104200-042

In imaging-selected ischemic stroke with unknown onset, alteplase increases favorable outcomes and death at 90 d

Ann Intern Med. 2021 Apr;174(4):JC42. doi: 10.7326/ACPJ202104200-042. Epub 2021 Apr 6.

Author

Michael D Hill¹

Affiliation

¹ University of Calgary and Hotchkiss Brain Institute & Foothills Medical Centre, Calgary, Alberta, Canada (M.D.H.).

PMID: 33819060
DOI: 10.7326/ACPJ202104200-042

Abstract

Thomalla G, Boutitie F, Ma H, et al. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet. 2020;396:1574-84. 33176180.

Keywords: Brain ischemia, Stroke, Thrombolytic therapy.

Publication types

Comment

MeSH terms

Brain Ischemia* / diagnostic imaging
Brain Ischemia* / drug therapy
Fibrinolytic Agents / adverse effects
Humans
Ischemic Stroke*
Stroke* / diagnostic imaging
Stroke* / drug therapy
Thrombolytic Therapy
Tissue Plasminogen Activator / adverse effects
Treatment Outcome

Substances

Fibrinolytic Agents
Tissue Plasminogen Activator