Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1874-1889. doi: 10.1161/ATVBAHA.120.315522. Epub 2021 Apr 1.

Abstract

[Figure: see text].

Keywords: aorta; atherosclerosis; cholesterol; foam cells; lipid; smooth muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter 1 / metabolism
  • Animals
  • Aorta, Abdominal / metabolism*
  • Aorta, Abdominal / pathology
  • Aortic Diseases / genetics
  • Aortic Diseases / metabolism*
  • Aortic Diseases / pathology
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism*
  • Atherosclerosis / pathology
  • Biomarkers / blood
  • Cell Transdifferentiation
  • Cells, Cultured
  • Cholesterol / blood*
  • Disease Models, Animal
  • Disease Progression
  • Down-Regulation
  • Female
  • Foam Cells / metabolism
  • Foam Cells / pathology
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Muscle, Smooth, Vascular / metabolism
  • Muscle, Smooth, Vascular / pathology
  • Myocytes, Smooth Muscle / metabolism
  • Myocytes, Smooth Muscle / pathology
  • Plaque, Atherosclerotic*
  • Proteolysis
  • Receptors, LDL / deficiency
  • Receptors, LDL / genetics
  • Tissue Inhibitor of Metalloproteinase-4
  • Tissue Inhibitor of Metalloproteinases / deficiency*
  • Tissue Inhibitor of Metalloproteinases / genetics

Substances

  • ABCA1 protein, mouse
  • ATP Binding Cassette Transporter 1
  • Biomarkers
  • Receptors, LDL
  • Tissue Inhibitor of Metalloproteinases
  • Cholesterol